We report the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget�s disease that showed\r\nthe validity of trastuzumab monotherapy. We administered trastuzumab at a loading dose of 8 mg/kg i.v., followed by a 6 mg/kg\r\nmaintenance dose every three weeks according to a protocol for HER2-positive metastatic breast cancers and a near-complete\r\nresponse was achieved after the tenth infusion. The patient experienced a moderate headache and flushing during the first infusion,\r\nbut had no advanced effects during subsequent infusions with ibuprofen and d-chlorpheniramine maleate. Given the dramatic\r\nresponse, the patient has had 17 infusions of trastuzumab with no disease progression. Thus, trastuzumab has few side effects and\r\nis well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease.
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